Neuroprotective Potentials Of Extracts From Moringa Oleifera And Musa Sapientum Against Cadmium Chloride-Induced Neurotoxicity In Rats Cerebri

Authors

  • Adelaja Akinlolu Federal University of Health Sciences Otukpo
  • Mubarak Ameen Department of Chemistry, Faculty of Physical Sciences, University of Ilorin, Kwara State,
  • Taofeek Garuba Department of Plant Biology, Faculty of Life Sciences, University of Ilorin
  • Nnaemeka Asogwa Central Research Laboratory, Tanke, Ilorin, Kwara State
  • Zainab Arowolo Department of Chemistry, Faculty of Physical Sciences, University of Ilorin, Kwara State
  • Bamidele Fagbohunka Department of Biochemistry, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Kayode Odubela Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Veronica Patrick Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Oluwatosin Ajayi Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Seun Kalejaiye Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Anthony Okeowo Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Temitope Akintunde Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Fatimah Oduntan Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Sinmisola Osibowale Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Esther Adebimpe Banjo Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun State
  • Adewole Okunlola Department of Mathematics, Faculty of Science, University of Medical Sciences Ondo, Ondo State

DOI:

https://doi.org/10.47743/jemb-2025-225

Keywords:

Cadmium, Moringa oleifera, Musa sapientum, neurotoxicity, neuroprotection

Abstract

Cadmium (Cd)-exposure in humans causes nervous system dysfunctions. In rats, Cd-exposure resulted in increases of nitric oxide and lipid peroxidation levels in the hippocampus. This study evaluated the neuroprotective potential of active drug compounds extracted from Moringa oleifera leaves (MO11) and Musa sapientum suckers (MS06) in cadmium chloride (CdCl2)-induced neurotoxicity in rats. Adult male Wistar rats totalling 24 in number, were grouped randomly into six with four rats per group. Group 1 served as the control. An intraperitoneal single-dose of CdCl2 was administered to rats of Groups 2 to 4 and 6 on Day 1. MO11-dose, MO11+MS06-doses, and Doxorubicin-dose were respectively administered to rats of Groups 3, 4, and 6 for post-treatment of CdCl2-induced neurotoxicity. Rats of Group 5 were administered Olive Oil-dose (vehicle) for 17 days. Tissue concentrations of catalase, superoxide dismutase, cyclo-oxygenase-2 and cytochrome P450 in rats’ cerebri were determined using ELISA. Statistical analyses (p ≤ 0.05) of data were conducted using the Mann-Whitney U Test. Results showed increased catalase levels, similar superoxide dismutase levels, decreased cytochrome P450 levels and decreased cyclo-oxygenase-2 levels in rats of Groups 3, 4, and 6 in comparison with Group 2. The tested extracts impacted some levels of neuroprotection, neuroregeneration, antioxidant and anticancer capacities against neurotoxicity caused by CdCl2 exposure.

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Published

2025-02-07 — Updated on 2025-03-31

How to Cite

Akinlolu, A., Ameen, M., Garuba, T., Asogwa, N., Arowolo, Z., Fagbohunka, B., Odubela, K., Patrick, V., Ajayi, O., Kalejaiye, S., Okeowo, A., Akintunde, T., Oduntan, F., Osibowale, S., Banjo, E. A., & Okunlola, A. (2025). Neuroprotective Potentials Of Extracts From Moringa Oleifera And Musa Sapientum Against Cadmium Chloride-Induced Neurotoxicity In Rats Cerebri. Journal of Experimental and Molecular Biology, 26(1), 47–58. https://doi.org/10.47743/jemb-2025-225

Issue

Vol. 26 No. 1 (2025)

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