A functional polymorphism rs4938723 in the promoter of miR-34b/c is associated with an increased risk of lung cancer: A functional polymorphism rs4938723 in the promoter of miR-34b/c

Aycan ÇELİK; Sevim Karakas Celik; Erkan Arpacı; Hüseyin Ergin; Ercan ARICAN

doi:10.47743/jemb-2024-121

Authors

Aycan ÇELİK
Sevim Karakas Celik
Erkan Arpacı
Hüseyin Ergin
Ercan ARICAN Istanbul University

DOI:

https://doi.org/10.47743/jemb-2024-121

Keywords:

Lung cancer, polymorphisim, SNP, miR-34a, miR-34b/c, miR-125a

Abstract

Background: The expression level of some microRNAs (miRNAs) in lung cancer has been associated with an increased risk of cancer. miRNAs play a substantial role in the pathogenesis of human cancers. Because of that, miRNA polymorphisms can be important for carcinogenesis. MiR-34 is a family of miRNAs known to have reduced levels of expression in lung cancer and other human cancers (pancreas, colon). It functions like tumor suppressor and targets oncogenes like MET, RET, and RAB43. Also miR-125 family is related with many cancer types and targets P53, BCL2, VEGF, and EGFR.

Author Biographies

Aycan ÇELİK

Department of Molecular Biology and Genetics, Faculty of Science, Bulent Ecevit University, Zonguldak, 67100, Turkey,

Sevim Karakas Celik

Department of Medical Genetics, Faculty of Medicine, Bulent Ecevit University, Zonguldak, 67600, Turkey

Erkan Arpacı

Department of Medical Oncology, Kocaeli Gebze Medicalpark Hospital, Kocaeli, 41400, Turkey

Hüseyin Ergin

Department of Medical Oncology, Faculty of Medicine, Bulent Ecevit University, Zonguldak, 67600, Turkey,

References

Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007; 26: 745–752.

Chen CL, Hsu LI, Chiou HY, Hsueh YM, Chen SY, Wu MM, et al. Ingested arsenic, cigarette smoking, and lung cancer risk: A follow-up study in arseniasis-endemic areas in Taiwan. JAMA 2004; 292: 2984.

Esquela-Kerscher A, Slack FJ. Oncomirs—microRNAs with a role in cancer. Nat Rev Cancer 2016; 6: 259–269.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International journal of cancer 2015; 136(5).

Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19: 92-105.

Fu Y, & Cao F. MicroRNA-125a-5p regulates cancer cell proliferation and migration through NAIF1 in prostate carcinoma. OncoTargets and therapy 2015; 8: 3827.

Gallardo E, Navarro A, Viñolas N, Marrades RM, Diaz T, Gel B, et al. miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. Carcinogenesis 2009; 30(11): 1903-1909.

Gong J, Tong Y, Zhang HM, Wang K, Hu T, Shan G, et al. Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Human Mutation 2012; 33(1): 254-263.

Hashiguchi Y, Nishida N, Mimori K, Sudo T, Tanaka F, Shibata K, et al. Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance. International journal of oncology 2012; 40(5): 1477-1482.

Hermeking, H. The miR-34 family in cancer and apoptosis. Cell death and differentiation 2010; 17(2): 193.

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005; 65: 7065–7070.

Iwai N, Naraba H. Polymorphisms in human pre-miRNAs. Biochemical and biophysical research communications 2015; 331(4): 1439-1444.

Jiang L, Huang Q, Zhang S, Zhang Q, Chang J, Qiue X, t al. Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells. BMC cancer 2010; 10(1): 318.

Jiang, H., Ge, F., Hu, B., Wu L, Yang H, Wang H. rs35301225 polymorphism in miR-34a promotes development of human colon cancer by deregulation of 3′ UTR in E2F1 in Chinese population. Cancer cell international 2017; 17(1): 39.

Jiao L, Zhang J, Dong Y, Duan B, Yu H, Sheng H. et al, Association between miR-125a rs12976445 and survival in breast cancer patients. American journal of translational research 2014; 6(6): 869.

Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J. Exploration of tumor suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res. 2008; 68: 2094–2105.

Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010; 11(9): 597–610.

Lehmann TP, Korski K, Ibbs M, Zawierucha P, Grodecka-Gazdecka S, Jagodzinski PP. rs12976445 variant in the pri‑miR‑125a correlates with a lower level of hsa‑miR‑125a and ERBB2 overexpression in breast cancer patients. Oncology letters 2013; 5(2): 569-573.

Li L, Wu J, Sima X, Bai P, Deng W, Deng X, et al. Interactions of miR-34b/c and TP-53 polymorphisms on the risk of nasopharyngeal carcinoma. Tumor Biology 2013; 34(3): 1919-1923.

Li W, Duan R, Kooy F, Sherman SL, Zhou W, Jin P. Germline mutation of microRNA-125a is associated with breast cancer. J Med Genet 2009; 46(5): 358–60.

Lodygin D, Tarasov V, Epanchintsev A, Berking C, Knyazeva T, Körner H, et al. Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 2008; 7: 2591–2600.

Na II, Byun, BH, Kim KM, Cheon GJ, Choe DH, et al. 18F-FDG uptake and EGFR mutations in patients with non-small cell lung cancer: a single-institution retrospective analysis. Lung Cancer 2010; 67(1): 76-80.

Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, et al. MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res. 2011; 17: 2725–2733.

Pan XM, Sun RF, Li ZH, Guo XM, Qin HJ, Gao LB, et al. Pri-miR-34b/c rs4938723 polymorphism is associated with a decreased risk of gastric cancer. Genetic testing and molecular biomarkers 2015; 19(4): 198-202.

Quan H, Yuan T, Hao J. A microRNA‑125a variant, which affects its mature processing, increases the risk of radiation‑induced pneumonitis in patients with non‑small‑cell lung cancer. Molecular Medicine Reports 2018; 18: 4079-4086.

Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res 2004; 14: 1902–1910.

Shastry BS. SNPs: impact on gene function and phenotype. Methods Mol. Biol. 2009; 578: 3-22.

Shields, Peter G. Molecular epidemiology of smoking and lung cancer. Oncogene, 2002, 21(45): 6870-6876.

Son MS, Jang MJ, Jeon YJ, Kim WH, Kwon CI, Ko KH, et al. Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma. Gene 2013; 524(2): 156-160.

Spitz MR, Hong WK, Amos CI, Wu X, Schabath MB, Dong Q, et al. A risk model for prediction of lung cancer. J Natl Cancer Inst. 2007; 99: 715-26.

Sun YM, Lin KY, Chen YQ. Diverse functions of miR-125 family in different cell contexts. Journal of hematology & oncology 2013; 6(1): 6.

Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomuraet Y, et al. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 2008; 68: 4123–4132.

Wang RJ, Zheng YH, Wang P, Zhang JZ, et al. Serum miR-125a-5p, miR-145 and miR-146a as diagnostic biomarkers in non-small cell lung cancer. International journal of clinical and experimental pathology 2015; 8(1): 765.

Wang S, Huang J, Lyu H, Lee CK, Tan J, Wang J, Liu B. Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells. Cell death & disease 2013; 4(3): e556.

Welch C, Chen Y, Stallings RL. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 2007; 26(34): 5017.

Wynendaele J, Bohnke A, Leucci E, Nielsen SJ, Lambertz I, Hammer S, et al. An illegitimate microRNA target site within the 3′ UTR of MDM4 affects ovarian cancer progression and chemosensitivity. Cancer Res. 2010; 70(23): 9641–9.

Xu Y, Liu L, Liu J, Zhang Y, Zhu j, Chen J, et al. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Int J Cancer 2011; 128: 412–417.

Yan D, Zhou X, Chen X, Hu DN, Dong XD, Wang J, et al. MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met. Invest. Ophthalmol. Vis. Sci. 2008; 50: 1559-1565).

Yin J, Wang X, Zheng L, Shi Y, Wang L, Shao A, et al. Hsa-miR-34b/c rs4938723 T> C and hsa-miR-423 rs6505162 C> A polymorphisms are associated with the risk of esophageal cancer in a Chinese population. PloS one 2013; 8(11): e80570.

Yuan F, Sun R, Chen P, Liang Y, Ni S, Quan Y, et al. Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk. Tumor Biology 2016; 37(5): 6267-6273.

Zang Z, Guan W, Chen D, Han Y, Shi Z, Zhou J. Association Between microRNA-125a rs12976445 C> T Polymorphism and 18F-Fluorodeoxyglucose (18FDG) Uptake: Clinical and Metabolic Response in Patients with Non-Small Cell Lung Cancer. Medical science monitor: international medical journal of experimental and clinical research 2016; 22: 4186.