GENETIC VARIABILITY OF PHARMACOKINETICS AND PHARMACODYNAMICS OF ANALGESICS (LAYERED MEDICINE)

  • Neamtu Monica University of Medicine and Pharmacy Iasi
  • Alexandru Vasincu
  • Daniela Ababei
  • Oana Arcan
  • Delia Bulea
  • Razvan Nicolae Rusu
  • Veronica Bild
Keywords: analgesics, single nucleotide polymorphism, pharmacogenomics

Abstract

Pain therapy, the most widely spread disorder, tends more as other diseases, to administration of drug molecules targeted to the affected tissue at the right dose, or to the patient or patient groups (personalized medicine). A decisive determinant of this strategy is the genetic one, which is to some extent the basis of the variability of pharmacokinetic and pharmacodynamic response to analgesics in the patient population. The differences in action and response to analgesics are due in these cases to hyperfunctional or nonfunctional uni-nucleotide gene polymorphisms encoding enzyme-modified transport proteins or receptors involved in the biotransformation and dynamics of analgesics. Genomic testing increases therapeutic efficacy and avoids adverse effects especially in patients with long-term therapies.  

 

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CYP ALLELE Nomenclature Commitee (http://www.cypalleles .ki.se)

www.ncbi.nlm.nih.gov/SNP

Published
2019-09-20
How to Cite
Monica, N., Vasincu, A., Ababei, D., Arcan, O., Bulea, D., Rusu, R., & Bild, V. (2019). GENETIC VARIABILITY OF PHARMACOKINETICS AND PHARMACODYNAMICS OF ANALGESICS (LAYERED MEDICINE). Journal of Experimental and Molecular Biology, 20(1-2), 7-14. Retrieved from http://www.jemb.bio.uaic.ro/index.php/jemb/article/view/32
Section
Reviews