Acquired Antibiotic Resistance
DOI:
https://doi.org/10.47743/jemb-2022-66Keywords:
horizontal gene transfer, multidrug-resistant bacteria, plasmid, transposon, integronAbstract
Antibiotics are chemicals used to control bacterial infections, produced by microorganisms (fungi, some bacteria) or obtained synthetically or semi-synthetically. The discovery of antibiotics has revolutionized the medical system, reducing morbidity and mortality rates and improving quality and length of life. Antibiotics affect essential processes in the bacterial cell, but bacteria have adapted to their action by developing antibiotic resistance. Though multidrug-resistant bacteria have emerged, they threaten the healthcare system globally by making it difficult to find effective antibiotics. This review focuses on the mechanisms leading to acquired antibiotic resistance, namely mutations and horizontal gene transfer, and on mobile genetic elements associated with antibiotic resistance (plasmids, transposons, and integrons) that disperse antibiotic resistance genes between bacteria.
References
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Gillings, M. R. (2014): Integrons: past, present, and future. Microbiol Mol Biol Rev, 78(2): 257-77.
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Gorrie, C. L., Mirceta, M., Wick, R. R., Judd, L. M. et al. (2018): Antimicrobial-resistant Klebsiella pneumoniae carriage and infection in specialized geriatric care wards linked to acquisition in the referring hospital. Clin. Infect. Dis., 67: 161-170.
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Hooper, D. C. (2001): Emerging mechanisms of fluoroquinolone resistance. Emerg. Infect. Dis., 7: 337-341.
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Kohler, V., Keller, W., Grohmann, E. (2019): Regulation of Gram-positive conjugation. Front. Microbiol., 10, 1134.
Krahn, T., Wibberg, D., Maus, I., Winkler, A. et al. (2016): Intraspecies transfer of the chromosomal Acinetobacter baumannii blaNDM-1 carbapenemase gene. Antimicrob. Agents Chemother,. 60: 3032-3040.
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Lambertsen, L., Rubio-Cosials, A., Patil, K. R., Barabas, O. (2017): Conjugative transposition of the vancomycin resistance carrying Tn1549: Enzymatic requirements and target site preferences. Molecular Microbiology, 107(5).
Launay, A., Ballard, S. A., Johnson, P. D. R., Grayson, L., Lambert, T. (2006): Transfer of Vancomycin resistance transposon Tn1549 from Clostridium symbiosum to Enterococcus spp. in the gut of gnotobiotic mice. Antimicrob Agents Chemother, 50: 1054-1062
Lerminiaux, N.A., Cameron, A. D. S. (2018): Horizontal transfer of antibiotic resistance genes in clinical environments. Canadian Journal of Microbiology, https://doi.org/10.1139/cjm-2018-0275
Lewis, T., Loman, N. J., Bingle, L., Jumaa, P. et al. (2010): High-throughput whole-genome sequencing to dissect the epidemiology of Acinetobacter baumannii isolates from a hospital outbreak. J. Hosp. Infect., 75: 37-41.
Liu, Y., Tong, Z., Shi, J., Jia, Y. et al. (2020): Correlation between Exogenous Compounds and the Horizontal Transfer of Plasmid-Borne Antibiotic Resistance Genes. Microorganisms, 8(8), 1211
Ludden, C., Reuter, S., Judge, K., Gouliouris et al. (2017): Sharing of carbapenemase-encoding plasmids between Enterobacteriaceae in UK sewage uncovered by MinION sequencing. Microb. Genom., 3(7): e000114.
Ma, C., Yang, X., Lewis, P. J. (2016): Bacterial transcription as a target for antibacterial drug development. Microbiol Mol Biol Rev,. 80:139-160.
Manson, J. M., Hancock, L. E., Gilmore, M. S. (2010): Mechanism of chromosomal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traits. Proc Natl Acad Sci USA, 107:12269-12274
Martin, J., Phan, H. T. T., Findlay, J., Stoesser, N. et al. (2017). Covert dissemination of carbapenemase-producing Klebsiella pneumoniae (KPC) in a successfully controlled outbreak: long- and short-read whole-genome sequencing demonstrate multiple genetic modes of transmission. J. Antimicrob. Chemother., 72: 3025-3034.
Marvaud, J. C., Mory, F., Lambert, T. (2011): Clostridium clostridioforme and Atopobium minutum clinical isolates with vanB-type resistance in France. J Clin Microbiol, 49:3436-3438
Mašlaňová, I., Stříbná, S., Doškař, J., Pantůček, R. (2016): Efficient plasmid transduction to Staphylococcus aureus strains insensitive to the lytic action of transducing phage. FEMS Microbiol. Lett., 363: fnw211.
Matilla, M. A., Salmond, G. P. C. (2014): Bacteriophage ϕMAM1, a Viunalikevirus, is a broad-host-range, high-efficiency generalized transducer that infects environmental and clinical isolates of the Enterobacterial genera Serratia and Kluyvera. Appl. Environ. Microbiol,. 80, 6446-6457.
Mulvey, M. R., Haraoui, L.-P., Longtin, Y. (2016): Multiple variants of Klebsiella pneumoniae producing carbapenemase in one patient. N. Engl. J. Med., 375: 2408-2410.
Munita, J. M., Arias, C. A. (2021): Mechanisms of Antibiotic Resistance. Microbiology Spectrum, DOI: https://doi.org/10.1128/microbiolspec.VMBF-0016-2015
Nadell, C. D., Xavier, J. B., Foster, K. R. (2009): The sociobiology of biofilms. FEMS Microbiol. Rev., 33: 206-224.
Nandi, S., Maurer, J. J., Hofacre, C., Summers, A. O. (2004): Gram-positive bacteria are a major reservoir of Class 1 antibiotic resistance integrons in poultry litter. Proc. Natl. Acad. Sci., 101: 7118-22.
Ochman, H., Lawrence, J. G., Groisman, E. A. (2000): Lateral gene transfer and the nature of bacterial innovation. Nature, 405: 299-304.
Ory, J., Bricheux, G., Togola, A., Bonnet, J. L. et al. (2016): Ciprofloxacin residue and antibiotic-resistant biofilm bacteria in hospital effluent. Environ. Pollut., 214: 635-645.
Osei Sekyere, J., Amoako, D. G. (2017): Genomic and phenotypic characterisation of fluoroquinolone resistance mechanisms in Enterobacteriaceae in Durban, South Africa. PLoS One, 12: e0178888.
Pagès, J. M., James, C. E., Winterhalter, M. (2008): The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria. Nat Rev Microbiol, 6:893-903.
Paterson, D. L., Bonomo, R. A. (2005): Extended-spectrum β-lactamases: a clinical update. Clin. Microbiol. Rev., 18: 657-686.
Phan, H. T. T., Stoesser, N., Maciuca, I. E., Toma, F. et al. (2018): Illumina short-read and MinION long-read WGS to characterize the molecular epidemiology of an NDM-1 Serratia marcescens outbreak in Romania. J. Antimicrob. Chemother., 73: 672-679.
Pontes, M. H., Groisman, E. A. (2020): A Physiological Basis for Nonheritable Antibiotic Resistance. ASM Journal, 11:3
Prudhomme, M., Attaiech, L., Sanchez, G., Martin, B., Claverys, J.-P. (2006): Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae. Science, 313: 89-92.
Quirós, P., Colomer-Lluch, M., Martínez-Castillo, A,; Miró, E. et al. (2014): Antibiotic resistance genes in the bacteriophage DNA fraction of human fecal samples. Antimicrob. Agents Chemother, 58, 606-609.
Rice, L. B., Carias, L. L., Susan, R., Hutton, R. A., Steven, M. (2010): Multiple copies of functional, Tet(M)-encoding Tn916-like elements in a clinical Enterococcus faecium isolate. Plasmid, 64: 150-155
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Published
2022-09-07
How to Cite
Iasmina, H. (2022). Acquired Antibiotic Resistance. Journal of Experimental and Molecular Biology, 23(1), 54–65. https://doi.org/10.47743/jemb-2022-66
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