Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa

2024-04-16T14:32:53+00:00

The ACE2 gene polymorphisms (rs143936283, rs146676783, and rs4646116) in infected and noninfected persons by SARS-CoV-2 in Burkina Faso. Our cross-sectional study population comprised 137 SARS-CoV-2 infected persons and 181 non-infected persons. Three ACE2 gene polymorphisms rs143936283, rs146676783, and rs4646116, were genotyped using the real-time PCR standard TaqMan allelic discrimination technique. The association between SARS-CoV-2 infection and the polymorphisms were evaluated by a binary logistic regression. There was no association between the polymorphisms rs143936283, rs4646116 haplotypes, and SARS-CoV-2 infection in our study population. However, in the female population, the heterozygous genotype CT of rs146676783 increased by two and half the risk (OR=2.58 95%CI (1.2-5.48), p= 0.014) of being infected by SARS-CoV-2. Additionally, carrying the homozygous minor allele (genotype TT) of rs146676783 increased by more than five and half the risk (OR=5.57 95%CI (1.64-18.78), p=0.006) of being infected by SARS-CoV-2 among females. This study showed that the ACE2 gene variant rs146676783 was associated with an increased risk of being infected by SARS-CoV-2 in females, suggesting a need for further investigation to contribute to a better understanding of the African COVID-19 enigma.

PERFORMANCE, HAEMATOLOGY AND SERUM BIOCHEMISTRY OF RABBIT BUCKS FED SUPPLEMENTAL LEVELS OF Saccharomyces cerevisiae

2024-04-16T14:32:49+00:00

This study was carried out to investigate the effect of Saccharomyces cerevisiae on growth performance, haematological and serum biochemical indices of rabbit bucks. Eighteen bucks were used for the study. They were assigned to three treatment groups with 6 bucks per treatment, replicated 3 times in a completely randomized design for twenty-eight (28) days. The bucks were allowed one week of acclimatization before the commencement of the study, during which they were fed commercial growers diets and forages. The bucks were fed a formulated ration supplemented with S. cerevisiae at 0.0, 0.3 and 0.6g respectively and were coded T1, T2 and T3 respectively. T1served as control. Growth parameters, haematological indices and serum chemistry were measured in the course of the study. The data collected were subjected to analysis of variance (ANOVA) using SPSS version 21, and means were separated using Duncan of same software. The results revealed that S. cerevisae did not have effect (p>0.05) on the growth parameters in the rabbit bucks. This study revealed that Saccharomyces cerevisiae did not have significant effect (p>0.05) in the PCV of bucks in the study as T1, T2 and T3 all had similar (p>0.05) PCV values of 39.00, 39.00 and 41.00% respectively. S. cerevisiae influenced (P<0.05) serum enzymes but did not have significant effect (p>0.05) on total protein, blood urea, ALT creatinine and glucose. In conclusion, dietary supplementation of S. cerevisiae at 0.60% did not have significant effect on growth parameters and most haematological and serum biochemical indices.

Journal of Experimental and Molecular Biology

Linkage between ACE2 Gene Polymorphisms and SARS-CoV-2 infection in Burkina Faso, sub-Saharan Africa

PERFORMANCE, HAEMATOLOGY AND SERUM BIOCHEMISTRY OF RABBIT BUCKS FED SUPPLEMENTAL LEVELS OF Saccharomyces cerevisiae